As a fertilizer, Neem has shown tremendous promise. Neem cake and Neem leaves are especially promising for this reason. In his book on Neem, Puri (1999) provided details about Neem seed cake as an inhibitor of manure and nitrification. The author has identified the possibility of using Neem cake after processing to partially replace poultry and cattle feed. Because of its residual limonoid content, Neem cake organic manure protects plant roots from nematodes, soil grubs and white ants. It also acts as a pesticide-induced natural fertilizer. Neem cake is commonly used for paddy, cotton, and sugarcane fertilization in India.
The use of Neem cake in Tectona Grandis (Teak), Acacia Nilotica (Gum Arabic), and other forest trees has shown a rise in dry matter. Neem cake is useful for insect and pest control. Seven types of activities (a) antifeedant (b) attractive (c) repellent (d) insecticide (e) nematicide (f) growth disruptor and (g) antimicrobial have been reported to have the bitter principles of soil and cake.